Research & Development

1. Custom synthesis and process improvement of API and intermediates.
2. Pilot studies of new molecules for clients.
3. Process optimisation and improvement of existing and new products.
4. Research for in-house applications (production of APIs/ intermediates and fine chemicals)

Arvee performs a wide range of Name Reactions viz. hydogenation, PTC based alkylations-O-, C-, S-, and N-alkylations, chiral chemistry, asymmetric syntheses etc, and handles reagents like azides, hydrides, boranes, organolithium derivatives, liquid HF among others, to tackle any chemistry. LDA and various Boronic acids are synthesized in house at all scales. These rigorous research and development activities result into substantial cost reduction of the chemistry in question, development of environment friendly processes and allow easy scale-up.

Custom synthesis at ARVEE

• Laboratory scale-up, commercial scale-up or post commercialization stages.
• There is a dedicated kilo lab at the R & D Centre itself. There is a pilot plant, SS, glass lined, high pressure y drier, and hydrogenators. All are cGMP compliant.
• The Company offers custom synthesis solutions that cater to outsourcing needs of customers

Under the Organic Custom Synthesis module, the Company offers a full range of services to meet the varying needs by utilizing established synthetic routes, modifying customer processes, designing novel routes with complete chemical, chromatographic, spectroscopic back up for starting materials, intermediates, reference compounds, metabolites, resolution of enantiomers, structural isomers etc.

As part of the Chemical Development service, the Company offers scale-up of existing processes, preparation of intermediates in milligrams to kilo lots, processes optimization, development and use of purification techniques and alternate process

Chemical Capabilities
Some of the chemical reactions undertaken at the production facilities are:

Asymmetric Synthesis Optical Resolution High Pressure Catalytic Hydrogenation Handling Butyl Lithium Bromination Chlorination Sulfonation Acylation Aklylation (-C,-N) Reduction

Grignard Cyanation Low Temperature (-80 C) Epoxidation Oxidations involving potassium permanganate, Hydrogen peroxide etc High temperature Condensation (+250 C) Friedel - Crafts